Association of <i>OPRM1</i> and <i>OPRD1</i> Polymorphisms with Pain and Opioid Adverse Reactions in Colorectal Cancer

Abstract excerpt

<h4>Background: </h4> /Objectives: Pain management in colorectal cancer is influenced by genetic variability in opioid receptor genes (OPRM1 and OPRD1), potentially affecting opioid efficacy and adverse drug reactions (ADR). This study evaluated the association of OPRM1 (rs1799971, rs510769) and OPRD1 (rs2236861) polymorphisms with pain severity, opioid efficacy, and ADR in Chilean colorectal cancer patients. <h4>...

Topics

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• Analgesics, Opioid
• ATP Binding Cassette Transporter, Subfamily B
• Catechol O-Methyltransferase
• Genotype
• Lung Neoplasms
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Receptors, Opioid, mu

Identifiers and source

Literature Corpus work

47e3eeca-9d26-5f67-8ab1-c1ea85007a6e

DOI

10.20944/preprints202412.1253.v1