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Article

Activation of JNK signaling mediates amyloid-ß-dependent cell death.

PloS one - 1 Jan 2011

Tare Meghana, Modi Rohan M, Nainaparampil Jaison J, Puli Oorvashi Roy, Bedi Shimpi, Fernandez-Funez Pedro, Kango-Singh Madhuri, Singh Amit

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is an age related progressive neurodegenerative disorder. One of the reasons for Alzheimer's neuropathology is the generation of large aggregates of Aß42 that are toxic in nature and induce oxidative stress, aberrant signaling and many other cellular alterations that trigger neuronal cell death. However, the exact mechanisms leading to cell death are not clearly understood....

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Identifiers

PMID: 21949710
DOI: 10.1371/journal.pone.0024361
PMCID: PMC3173392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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