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Article

Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in AppNLF Knock-In Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Barrett Tomás, Stangis Katherine A, Saito Takashi, Saido Takaomi, Park Kevin H J

Abstract excerpt

BACKGROUND: Aberrant cell cycle re-entry is a well-documented process occurring early in Alzheimer's disease (AD). This is an early feature of the disease and may contribute to disease pathogenesis. OBJECTIVE: To assess the effect of forced neuronal cell cycle re-entry in mice expressing humanized Aβ, we crossed our neuronal cell cycle re-entry mouse model with AppNLF knock-in (KI) mice. METHODS: Our neuronal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34219712
DOI: 10.3233/JAD-210091
PMCID: PMC8461670

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