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Article

Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

24 Jan 2013

Abstract excerpt

Normally post-mitotic neurons that aberrantly re-enter the cell cycle without dividing account for a substantial fraction of the neurons that die in Alzheimer's disease (AD). We now report that this ectopic cell cycle re-entry (CCR) requires soluble amyloid-β (Aβ) and tau, the respective building blocks of the insoluble plaques and tangles that accumulate in AD brain. Exposure of cultured wild type (WT) neurons...

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PMID: 23345405
DOI: 10.1242/jcs.1125880

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