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Article

MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability.

Protein science : a publication of the Protein Society - 1 Sept 2024

Bhopatkar Anukool A, Bhatt Nemil, Haque Md Anzarul, Xavier Rhea, Fung Leiana, Jerez Cynthia, Kayed Rakez

Abstract excerpt

The microtubule associated protein, tau, is implicated in a multitude of neurodegenerative disorders that are collectively termed as tauopathies. These disorders are characterized by the presence of tau aggregates within the brain of afflicted individuals. Mutations within the MAPT gene that encodes the tau protein form the genetic backdrop for familial forms of tauopathies, such as frontotemporal dementia (FTD),...

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Identifiers

PMID: 39145409
DOI: 10.1002/pro.5099
PMCID: PMC11325167

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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