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Article

Epigenetic Regulation of MicroRNAs in Acute Lymphoblastic Leukemia

22 Jan 2009

Abstract excerpt

PURPOSE: To identify microRNAs (miRNAs) epigenetically regulated in acute lymphoblastic leukemia (ALL). METHODS: We first examined ALL-derived cell lines for the presence of abnormal levels of two different histone modifications (trimethylation of H3 lysine 4 [K4H3me3] and dimethylation of H3 lysine 9 [K9H3me2]) in the 5'UTR regions around CpG islands of 78 miRNAs by chromatin immunoprecipitation (ChIP)-on-ChIP...

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PMID: 19164206
DOI: 10.1200/jco.2008.19.3441

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