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Article

Aberrant microRNA expression and its implications in the pathogenesis of leukemias

6 Sept 2012

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are a class of non-coding, endogenous, small RNAs that negatively regulate gene expression by inducing degradation or translational inhibition of target mRNAs. Aberrant expression of miRNAs appears to be a common characteristic of hematological malignancies including leukemias. AIM: Here we review the available data supporting a role of aberrant expression of miRNAs in the...

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PMID: 22956261
DOI: 10.1007/s13402-012-0095-3

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