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Article

Frequency of heterozygous Parkin mutations in healthy subjects: need for careful prospective follow-up examination of mutation carriers.

Parkinsonism & related disorders - 1 Jul 2009

Brüggemann Norbert, Mitterer Manfred, Lanthaler Andrea J, Djarmati Ana, Hagenah Johann, Wiegers Karin, Winkler Susen, Pawlack Heike, Lohnau Thora, Pramstaller Peter P, Klein Christine, Lohmann Katja

Abstract excerpt

The role of single heterozygous mutations in the putatively recessive Parkin gene in Parkinson disease (PD) is a vividly debated issue, partly caused by the largely unknown frequency of these mutations in healthy individuals. We investigated mutations in all 12 Parkin exons in 356 controls from two European populations including individuals from South Tyrol and Germany. None of the controls carried a homozygous...

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PMID: 19162522
DOI: 10.1016/j.parkreldis.2008.11.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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