Article
Deciphering the role of heterozygous mutations in genes associated with parkinsonism.
The Lancet. Neurology - 1 Jul 2007
Klein Christine, Lohmann-Hedrich Katja, Rogaeva Ekaterina, Schlossmacher Michael G, Lang Anthony E
Abstract excerpt
The association of six genes with monogenic forms of parkinsonism has unambiguously established that the disease has a genetic component. Of these six genes, LRRK2 (leucine-rich repeat kinase 2, or PARK8), parkin (PARK2), and PINK1 (PTEN-induced putative kinase 1, or PARK6) are the most clinically relevant because of their mutation frequency. Insights from initial familial studies suggest that LRRK2-associated...
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