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Article

Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients.

Annals of neurology - 1 Jan 2007

Kay Denise M, Moran Dawn, Moses Lina, Poorkaj Parvoneh, Zabetian Cyrus P, Nutt John, Factor Stewart A, Yu Chang-En, Montimurro Jennifer S, Keefe Robert G, Schellenberg Gerard D, Payami Haydeh

Abstract excerpt

OBJECTIVE: Homozygous or compound heterozygous parkin mutations cause juvenile parkinsonism. Heterozygous parkin mutations are also found in patients with typical Parkinson's disease (PD), but it is unclear whether a single "mutation" in a patient is related to disease or is coincidental, because the mutation frequency in control subjects is unknown. We present a comprehensive sequence analysis of parkin in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17187375
DOI: 10.1002/ana.21039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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