Article
Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines.
International journal for parasitology - 1 May 2009
Wang Christian W, Magistrado Pamela A, Nielsen Morten A, Theander Thor G, Lavstsen Thomas
Abstract excerpt
Plasmodium falciparum variant surface antigens (VSA) are targets of protective immunity to malaria. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and repetitive interspersed family (RIFIN) proteins are encoded by the two variable multigene families, var and rif genes, respectively. Whereas PfEMP1s are known to mediate cytoadhesion, the function of RIFINs is unknown. The sequence diversity and...
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