Article
Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines.
PloS one - 1 Jan 2009
Tiziani Stefano, Lodi Alessia, Khanim Farhat L, Viant Mark R, Bunce Christopher M, Günther Ulrich L
Abstract excerpt
Combined bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) exert unexpected antileukaemic activities against acute myeloid leukaemia (AML) and these activities are associated with the generation of reactive oxygen species (ROS) within the tumor cells. Although the generation of ROS by these drugs is supported by preceding studies including our own, the interrelationship between the cellular effects of the...
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