Predicting protein evolution in vitro by phage escape technology.

Abstract excerpt

The relationship between host and pathogen is inherently dynamic at the genetic level. A plethora of host defensive systems have evolved to counteract and/or eliminate invading pathogens. These strategies exert selection pressure upon the pathogen, leading to the emergence of mechanisms to combat the host including immune evasion and resistance. Consequently, effective control of rapidly evolving diseases is...

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