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Article

Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort.

Breast cancer research and treatment - 1 Oct 2009

Henry N Lynn, Rae James M, Li Lang, Azzouz Faouzi, Skaar Todd C, Desta Zereunesay, Sikora Matthew J, Philips Santosh, Nguyen Anne T, Storniolo Anna Maria, Hayes Daniel F, Flockhart David A, Stearns Vered

Abstract excerpt

Women with reduced CYP2D6 activity have low endoxifen concentrations and likely worse long term benefits from tamoxifen. We investigated the association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. We collected hot flash frequency and severity data over 12 months from 297 women initiating tamoxifen. We performed CYP2D6 genotyping using the AmpliChip CYP450 test and correlated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19153830
DOI: 10.1007/s10549-009-0309-1
PMCID: PMC2746261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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