Article
Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial.
British journal of cancer - 10 Jul 2012
Sestak I, Kealy R, Nikoloff M, Fontecha M, Forbes J F, Howell A, Cuzick J
Abstract excerpt
BACKGROUND: Several studies have reported discordant results regarding the impact of the CYP2D6 phenotype on both the effectiveness and the degree of endocrine symptoms associated with tamoxifen. Other studies have suggested that menopausal symptoms may be a predictive factor to tamoxifen response. METHODS: We investigated the relationship between the CYP2D6-predicted phenotype and tamoxifen response in a nested...
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