Article

Tamoxifen Dose Escalation in CYP2D6 Poor Metabolizer Breast Cancer Patients and Associated Side Effects

2024-10-01

Abstract excerpt

<h4>Aims: </h4> CYP2D6 is a key enzyme for metabolizing tamoxifen into active metabolites, but polymorphisms in this enzyme lead to varying metabolic capacities. Increasing the tamoxifen dose in patients with deficient CYP2D6 metabolism can elevate endoxifen levels to those of patients with normal phenotypes. This study examines the impact of increasing the dose of tamoxifen on toxicity in poor metabolizers of the...

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Literature Corpus work: bd3094f8-0a77-54dc-b2b8-d28a3afe3aea
DOI: 10.22541/au.172776789.93792455/v1

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