Article
CYP2D6 genotyping and tamoxifen: an unfinished story in the quest for personalized medicine.
Seminars in oncology - 1 Apr 2011
de Souza Jonas A, Olopade Olufunmilayo I
Abstract excerpt
The philosophy behind personalized medicine is that each patient has a unique biologic profile that should guide the choice of therapy, resulting in an improved treatment outcome, ideally with reduced toxicity. Thus, there has been increasing interest in identifying genetic variations that are predictive of a drug's efficacy or toxicity. Although it is one of the most effective drugs for treating breast cancer,...
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