Article
CYP2D6 genotype in relation to hot flashes as tamoxifen side effect in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
Breast cancer research and treatment - 1 Jan 2014
Dezentjé Vincent O, Gelderblom Hans, Van Schaik Ron H N, Vletter-Bogaartz Judith M, Van der Straaten Tahar, Wessels Judith A M, Kranenbarg Elma Meershoek-Klein, Berns Els M, Seynaeve Caroline, Putter Hein, Van de Velde Cornelis J H, Nortier Johan W R, Guchelaar Henk-Jan
Abstract excerpt
In tamoxifen-treated breast cancer patients the occurrence of hot flashes may be associated with effective estrogen receptor antagonism dependent on genetic variations of metabolic enzymes and the estrogen receptor. Early breast cancer patients who were randomized to receive tamoxifen, followed by exemestane within the tamoxifen exemestane adjuvant multinational trial were genotyped for five CYP2D6 alleles....
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