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Article

The fixation probability of rare mutators in finite asexual populations.

Genetics - 1 Apr 2009

Wylie C Scott, Ghim Cheol-Min, Kessler David, Levine Herbert

Abstract excerpt

A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100-fold have been observed to spontaneously emerge and achieve high frequencies in natural populations and in long-term laboratory evolution experiments with Escherichia coli. In principle, the fixation of mutator alleles is...

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Identifiers

PMID: 19153261
DOI: 10.1534/genetics.108.094532
PMCID: PMC2666523

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