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Article

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.

Human molecular genetics - 1 Apr 2009

Medina Pedro P, Castillo Sandra D, Blanco Sandra, Sanz-Garcia Marta, Largo Cristina, Alvarez Sara, Yokota Jun, Gonzalez-Neira Ana, Benitez Javier, Clevers Hans C, Cigudosa Juan C, Lazo Pedro A, Sanchez-Cespedes Montse

Abstract excerpt

The search for oncogenes is becoming increasingly important in cancer genetics because they are suitable targets for therapeutic intervention. To identify novel oncogenes, activated by gene amplification, we analyzed cDNA microarrays by high-resolution comparative genome hybridization and compared DNA copy number and mRNA expression levels in lung cancer cell lines. We identified several amplicons (5p13, 6p22-21,...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Chromosomes, Human, Pair 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Gene Dosage

Share to Gene Expression Regulation, Neoplastic

Share to Mutant Proteins

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Source

Identifiers

PMID: 19153074
DOI: 10.1093/hmg/ddp034

Genes

SOX4
RHOA
SRY

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.PMID 19153074Read ↗

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