Article
Polymorphisms in estrogen metabolism and estrogen pathway genes and the risk of miscarriage.
Archives of gynecology and obstetrics - 1 Sept 2009
Cupisti S, Fasching Peter A, Ekici A B, Strissel P L, Loehberg C R, Strick R, Engel J, Dittrich R, Beckmann M W, Goecke T W
Abstract excerpt
PURPOSE: This study investigated genetic variations in the estrogen pathway and their association with miscarriages. METHODS: A total of 483 patients were recruited from a comprehensive control group for case-control studies. Three variants of the CYP19A1 gene (rs10046, rs4646 and rs700519) and one variant each of the estrogen (ESR1) and progesterone (PGR) receptor genes (rs3020314 and rs1042838) were...
