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Article

Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.

Human reproduction (Oxford, England) - 1 Oct 2010

Hanna Courtney W, Bretherick Karla L, Liu Chi-Chao, Stephenson Mary D, Robinson Wendy P

Abstract excerpt

BACKGROUND: Recurrent miscarriage affects 1-2% of couples trying to conceive, and is idiopathic in nearly half. Female fertility is controlled by the hypothalamus-pituitary-ovarian (HPO) axis and we hypothesize that genetic polymorphisms affecting the function of genes involved in regulating the HPO axis will be associated with recurrent miscarriage. METHODS: Whole peripheral blood DNA from 227 women with...

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Share to Abortion, Habitual
Share to Activin Receptors, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor beta

Share to Hypothalamo-Hypophyseal System

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Share to Pituitary-Adrenal System

Share to Receptors, Glucocorticoid

Share to Receptors, Prolactin

Source

Identifiers

PMID: 20716560
DOI: 10.1093/humrep/deq211

Genes

ACVR1
ESR2
PRLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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