Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2009

Balachandran Kartik, Sucosky Philippe, Jo Hanjoong, Yoganathan Ajit P

Abstract excerpt

Matrix metalloproteinases (MMPs) and cathepsins are proteolytic enzymes that are upregulated in diseased aortic valve cusps. The objective of this study was to investigate whether elevated cyclic stretch causes an increased expression and activity of these proteolytic enzymes in the valve cusp. Circumferentially oriented fresh porcine aortic valve cusp sections were stretched to 10% (physiological), 15%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Valve
Share to Bioreactors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsins

Share to Extracellular Matrix

Share to Heart Valve Diseases

Share to Organ Culture Techniques

Share to Stress, Mechanical

Share to Tissue Inhibitor of Metalloproteinase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 19151254
DOI: 10.1152/ajpheart.00900.2008
PMCID: PMC12616545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.PMID 19151254Read ↗

Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast.Semantic proximity Read ↗

Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves.Semantic proximity Read ↗

Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification.Semantic proximity Read ↗

ER stress dependent microparticles derived from smooth muscle cells promote endothelial dysfunction during thoracic aortic aneurysm and dissection.Semantic proximity Read ↗

Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.Semantic proximity Read ↗

The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation.Semantic proximity Read ↗

Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves.Semantic proximity Read ↗

Influence of Clinically Relevant Mechanical Forces on Vascular Smooth Muscle Cells Under Chronic High Glucose: An In Vitro Dynamic Disease Model.Semantic proximity Read ↗

Dystrophin-deficient myocardium is vulnerable to pressure overload in vivoSemantic proximity Read ↗

Excessive tensile strain induced the change in chondrocyte phenotype.Semantic proximity Read ↗

Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha.Semantic proximity Read ↗

Characterisation of elastin and collagen in aortic bioprosthesesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.