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Article

Excessive tensile strain induced the change in chondrocyte phenotype.

Acta of bioengineering and biomechanics - 1 Jan 2018

Zhong Dongyan, Chen X I, Zhang Wen, Luo Zong-Ping

Abstract excerpt

PURPOSE: Chondrocyte extracellular matrix type II collagen and proteoglycans ensure an important compression-bearing structure in synovial joint. However, much more type I collagen is generated in osteoarthritis, which implies the presence of abnormal tensile strain in cartilage. We hypothesize that tensile stress influences chondrocyte phenotype at the cellular level, leading to potential osteoarthritis....

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PMID: 30220711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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