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Article

ER stress dependent microparticles derived from smooth muscle cells promote endothelial dysfunction during thoracic aortic aneurysm and dissection.

Clinical science (London, England : 1979) - 1 Jun 2017

Jia Li-Xin, Zhang Wen-Mei, Li Tao-Tao, Liu Yan, Piao Chun-Mei, Ma You-Cai, Lu Yu, Wang Yuan, Liu Ting-Ting, Qi Yong-Fen, Du Jie

Abstract excerpt

The degeneration of vascular smooth muscle cell(s) (SMC) is one of the key features of thoracic aortic aneurysm and dissection (TAAD). We and others have shown that elevated endoplasmic reticulum (ER) stress causes SMC loss and TAAD formation, however, the mechanism of how SMC dysfunction contributes to intimal damage, leading to TAAD, remains to be explored. In the present study, in vitro assay demonstrated that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28468950
DOI: 10.1042/CS20170252
PMCID: PMC5461939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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