Article
[Mutations in sarcomeric genes MYH7, MYBPC3, TNNT2, TNNI3, and TPM1 in patients with hypertrophic cardiomyopathy].
Revista espanola de cardiologia - 1 Jan 2009
García-Castro Mónica, Coto Eliecer, Reguero Julián R, Berrazueta José R, Alvarez Victoria, Alonso Belén, Sainz Rocío, Martín María, Morís Cesar
Abstract excerpt
INTRODUCTION AND OBJECTIVES: Mutation of a sarcomeric gene is the most frequent cause of hypertrophic cardiomyopathy. For each such gene, however, previous studies have reported a range of different mutation frequencies, and clinical manifestations have been highly heterogeneous, both of which limit the use of genetic information in clinical practice. Our aim was to determine the frequency of mutations in the...
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