Article
A molecular screening strategy based on beta-myosin heavy chain, cardiac myosin binding protein C and troponin T genes in Italian patients with hypertrophic cardiomyopathy.
Journal of cardiovascular medicine (Hagerstown, Md.) - 1 Aug 2006
Girolami Francesca, Olivotto Iacopo, Passerini Ilaria, Zachara Elisabetta, Nistri Stefano, Re Federica, Fantini Silvia, Baldini Katia, Torricelli Francesca, Cecchi Franco
Abstract excerpt
BACKGROUND: Mutations causing hypertrophic cardiomyopathy (HCM) have been described in nine different genes of the sarcomere. Three genes account for most known mutations: beta-myosin heavy chain (MYH7), cardiac myosin binding protein C (MYBPC3) and cardiac troponin T (TNNT2). Their prevalence in Italian HCM patients is unknown. Thus, we prospectively assessed a molecular screening strategy of these three genes...
Topics
- Cardiomyopathy, Hypertrophic
- Carrier Proteins
- Chi-Square Distribution
- Chromatography, High Pressure Liquid
- DNA Mutational Analysis
- Female
- Genotype
- Humans
- Italy
- Male
- Myosin Heavy Chains
- Pedigree