Article
Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma.
Molecular cancer research : MCR - 1 Jan 2009
Gartside Michael G, Chen Huaibin, Ibrahimi Omar A, Byron Sara A, Curtis Amy V, Wellens Candice L, Bengston Ana, Yudt Laura M, Eliseenkova Anna V, Ma Jinghong, Curtin John A, Hyder Pilar, Harper Ursula L, Riedesel Erica, Mann Graham J, Trent Jeffrey M, Bastian Boris C, Meltzer Paul S, Mohammadi Moosa, Pollock Pamela M
Abstract excerpt
We report that 10% of melanoma tumors and cell lines harbor mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. These novel mutations include three truncating mutations and 20 missense mutations occurring at evolutionary conserved residues in FGFR2 as well as among all four FGFRs. The mutation spectrum is characteristic of those induced by UV radiation. Mapping of these mutations onto the known...
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