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Article

COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.

The Journal of biological chemistry - 20 Mar 2009

Stuttmann Johannes, Lechner Esther, Guérois Raphael, Parker Jane E, Nussaume Laurent, Genschik Pascal, Noël Laurent D

Abstract excerpt

Ubiquitination and proteasome-mediated degradation of proteins are crucial for eukaryotic physiology and development. The largest class of E3 ubiquitin ligases is made up of the cullin-RING ligases (CRLs), which themselves are positively regulated through conjugation of the ubiquitin-like peptide RUB/NEDD8 to cullins. RUB modification is antagonized by the COP9 signalosome (CSN), an evolutionarily conserved...

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Source

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Identifiers

PMID: 19147500
DOI: 10.1074/jbc.M809069200
PMCID: PMC2658085

Genes

CUL1
NEDD8
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.PMID 19147500Read ↗

The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development.Semantic proximity Read ↗

Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex.Semantic proximity Read ↗

Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase.Semantic proximity Read ↗

Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function.Semantic proximity Read ↗

The Arabidopsis F-box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway.Semantic proximity Read ↗

Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.Semantic proximity Read ↗

The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses.Semantic proximity Read ↗

Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response.Semantic proximity Read ↗

The COP9 signalosome controls jasmonic acid synthesis and plant responses to herbivory and pathogens.Semantic proximity Read ↗

Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex.Semantic proximity Read ↗

Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana.Semantic proximity Read ↗

Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.Semantic proximity Read ↗

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