Article
Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response.
Science (New York, N.Y.) - 18 May 2001
Schwechheimer C, Serino G, Callis J, Crosby W L, Lyapina S, Deshaies R J, Gray W M, Estelle M, Deng X W
Abstract excerpt
The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis. Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCFTIR1. Furthermore, we found that the COP9 signalosome and SCFTIR1 interacted...
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