Article
The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.
Gynecologic oncology - 1 Mar 2009
Heubner Martin, Riemann Kathrin, Otterbach Friedrich, Kimmig Rainer, Kasimir-Bauer Sabine, Siffert Winfried, Wimberger Pauline
Abstract excerpt
OBJECTIVES: The precise role of gonadotropins in the carcinogenesis of epithelial ovarian cancer remains uncertain. Recently, the haplotype of two single nucleotide polymorphisms, Thr307Ala (rs6165) and Asn680Ser (rs6166), has been described as a risk factor for ovarian cancer in Chinese women. In this study we investigated the impact of this haplotype regarding the risk to develop ovarian cancer as well as...
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