Article
Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk.
Cancer research - 1 Jul 2005
Terry Kathryn L, De Vivo Immaculata, Titus-Ernstoff Linda, Shih Mei-Chiung, Cramer Daniel W
Abstract excerpt
Biological and epidemiologic evidence suggest that androgen or its receptor may play a role in ovarian cancer pathogenesis. The most notable genetic factor influencing androgen receptor (AR) activity is the functional cytosine, adenine, guanine (CAG) repeat in which length is inversely proportional to its transactivational activity. Additional genetic variation due to single nucleotide polymorphisms in the AR...
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