Expression level drives the pattern of selective constraints along the insulin/Tor signal transduction pathway in Caenorhabditis.

Abstract excerpt

Genes do not act in isolation but perform their biological functions within genetic pathways that are connected in larger networks. Investigation of nucleotide variation within genetic pathways and networks has shown that topology can affect the rate of protein evolution; however, it remains unclear whether a same pattern of nucleotide variation is expected within functionally similar networks and whether it may...

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