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Article

Regulation of the pyrimidine salvage pathway by the FUR1 gene product of Saccharomyces cerevisiae.

Current genetics - 1 May 1991

Kern L, de Montigny J, Lacroute F, Jund R

Abstract excerpt

In Saccharomyces cerevisiae, the protein encoded by the FUR1 gene is absolutely required for the expression of uracil phosphoribosyl transferase activity. The occurrence of semi-dominant mutations for 5-fluorouracil-(5FU)-resistance at this locus led us to clone and sequence the semi-dominant fur1-5 allele. A single point mutation, resulting in the substitution of arginine 134 for serine, is responsible for this...

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PMID: 1913872
DOI: 10.1007/BF00309592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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