Article
The physical state of fibronectin matrix differentially regulates morphogenetic movements in vivo.
Developmental biology - 15 Mar 2009
Rozario Tania, Dzamba Bette, Weber Gregory F, Davidson Lance A, DeSimone Douglas W
Abstract excerpt
This study demonstrates that proper spatiotemporal expression and the physical assembly state of fibronectin (FN) matrix play key roles in the regulation of morphogenetic cell movements in vivo. We examine the progressive assembly and 3D fibrillar organization of FN and its role in regulating cell and tissue movements in Xenopus embryos. Expression of the 70 kD N-terminal fragment of FN blocks FN fibril assembly...
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