Article
[Effect of mutation Arg9lGly on the thermal stability of beta-tropomyosin].
Biofizika - 1 Jan 2000
Nevzorov I A, Redwood C S, Levitskiĭ D I
Abstract excerpt
The mutation Arg91Gly (R91G) in beta-tropomyosin (beta-TM) is known to cause distal arthrogryposis, a severe congenital disorder of muscle tissues. To elucidate how this mutation affects the structural properties of beta-TM, the thermal unfolding of beta-TM carrying mutation Arg91Gly was compared with that of the wild type protein. It was shown by differential scanning calorimetry and circular dichroism that this...
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