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Article

The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.

Endocrinology - 1 Dec 2012

Couture Jean-Philippe, Nolet Guylaine, Beaulieu Elaine, Blouin Richard, Gévry Nicolas

Abstract excerpt

Adipogenesis, the biological process by which preadipocytes differentiate into mature fat cells, is coordinated by a tightly regulated gene expression program. Indeed, it has been reported that a large number of genetic events, from fat cell-specific transcription factors expression, such as the master regulator of fat cell differentiation peroxisome proliferator-activated receptor (PPAR)γ2 to epigenetic...

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PMID: 23064015
DOI: 10.1210/en.2012-1380

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