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Article

A fluorescence microscopy based genetic screen to identify mutants altered for interactions with host cells.

Journal of microbiological methods - 1 Oct 2000

Guy R L, Gonias L A, Stein M A

Abstract excerpt

The study of microbial intracellular pathogenesis has benefited from the application of immunofluorescence microscopy to characterize interactions of the pathogen with host cells. Unfortunately, immunofluorescence microscopy is impractical for screening the large number of bacterial mutants necessary to represent the entire genome of the pathogen. Screening has been limited due to the lack of materials suitable...

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PMID: 11018269
DOI: 10.1016/s0167-7012(00)00188-3

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