Article
Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.
British journal of cancer - 27 Jan 2009
Pearce C L, Near A M, Van Den Berg D J, Ramus S J, Gentry-Maharaj A, Menon U, Gayther S A, Anderson A R, Edlund C K, Wu A H, Chen X, Beesley J, Webb P M, Holt S K, Chen C, Doherty J A, Rossing M A, Whittemore A S, McGuire V, DiCioccio R A, Goodman M T, Lurie G, Carney M E, Wilkens L R, Ness R B, Moysich K B, Edwards R, Jennison E, Kjaer S K, Hogdall E, Hogdall C K, Goode E L, Sellers T A, Vierkant R A, Cunningham J M, Cunningham J C, Schildkraut J M, Berchuck A, Moorman P G, Iversen E S, Cramer D W, Terry K L, Vitonis A F, Titus-Ernstoff L, Song H, Pharoah P D P, Spurdle A B, Anton-Culver H, Ziogas A, Brewster W, Galitovskiy V, Chenevix-Trench G
Abstract excerpt
The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control. The Ovarian Cancer Association Consortium (OCAC) identified 10 single-nucleotide polymorphisms (SNPs) in genes in these pathways, which had been genotyped by Consortium members and a pooled analysis of these data was conducted. Three of the 10 SNPs showed...
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