Systematic evaluation of the association between a missense variant in XRCC3 gene splicing site and the pathogenesis of ovarian cancer.

doi:10.1042/BSR20230462

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Article

Systematic evaluation of the association between a missense variant in XRCC3 gene splicing site and the pathogenesis of ovarian cancer.

Bioscience reports - 28 Jun 2023

Liang Qiulian, Huang Gongchen, Zhong Ping, Deng Dengting, Yang Lin, Yu Xiangyuan

Abstract excerpt

The effects and underlying mechanism of XRCC3 rs861539 on the risk of ovarian cancer (OC) are still unclear. Therefore, a meta-analysis of 10 studies containing 6,375 OC cases and 10,204 controls was performed for this topic. Compared with GG genotype, GA + AA genotypes could significantly decrease the OC risk, odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were 0.89 (0.83-0.95) and...

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PMID: 37212185
DOI: 10.1042/BSR20230462
PMCID: PMC10272963

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