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Article

Role of genetic polymorphisms and ovarian cancer susceptibility.

Molecular oncology - 1 Apr 2009

Fasching Peter A, Gayther Simon, Pearce Leigh, Schildkraut Joellen M, Goode Ellen, Thiel Falk, Chenevix-Trench Georgia, Chang-Claude Jenny, Wang-Gohrke Shan, Ramus Susan, Pharoah Paul, Berchuck Andrew

Abstract excerpt

The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very high lifetime risk of ovarian cancer (10-60%) and to some extent, increased risks of fallopian tube and peritoneal cancer. These highly lethal cancers are almost...

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Identifiers

PMID: 19383379
DOI: 10.1016/j.molonc.2009.01.008
PMCID: PMC5527888

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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