Article
Breast cancer cell response to genistein is conditioned by BRCA1 mutations.
Biochemical and biophysical research communications - 13 Feb 2009
Privat Maud, Aubel Corinne, Arnould Stéphanie, Communal Yves, Ferrara Marc, Bignon Yves-Jean
Abstract excerpt
Soy phytoestrogens, among which genistein, seem to protect from breast cancer development. In order to study the role of the breast tumour suppressor BRCA1 in response to genistein, we used a new breast cancer cell model: the SUM1315MO2 cell line carrying the 185delAG BRCA1 mutation, which we stably transfected with a plasmid encoding wild-type BRCA1. We showed that growth of BRCA1 mutant cells was strongly...
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