Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of the Phytoestrogens Genistein and Daidzein on BRCA2 Tumor Suppressor Gene Expression in Breast Cell Lines

1 Mar 2003

Abstract excerpt

A high intake of isoflavones is associated with a reduction of breast cancer among Japanese women. The aim of this study was to quantify BRCA2 tumor suppressor gene expression after treatment of cells with the phytoestrogens daidzein and genistein, the main compounds of soy. The effects of 5 microg/ml genistein and 20 microg/ml daidzein on BRCA2 expression were studied in two human mammary tumor cell lines, MCF7...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Digestive system and related health
Share to Nutrition, Genetics, and Disease
Share to Phytoestrogen effects and research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12881020
DOI: 10.1207/s15327914nc4502_15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of the Phytoestrogens Genistein and Daidzein on BRCA2 Tumor Suppressor Gene Expression in Breast Cell LinesPMID 12881020Read ↗

Gene Expression Profiling of Breast Cancer Cell Lines in Response to Soy Isoflavones Using a Pangenomic Microarray ApproachSemantic proximity Read ↗

The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled StudySemantic proximity Read ↗

Can Soy Phytoestrogens Decrease DNA Methylation in <i>BRCA1</i> and <i>BRCA2</i> Oncosuppressor Genes in Breast Cancer?Semantic proximity Read ↗

Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray studySemantic proximity Read ↗

DNA Methylation and Soy Phytoestrogens: Quantitative Study in DU-145 and PC-3 Human Prostate Cancer Cell LinesSemantic proximity Read ↗

Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue transgenic rats.Semantic proximity Read ↗

Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines.Semantic proximity Read ↗

Potential therapeutic mechanism of genistein in breast cancer involves inhibition of cell cycle regulationSemantic proximity Read ↗

Genistein affects HER2 protein concentration, activation, and promoter regulation in BT-474 human breast cancer cellsSemantic proximity Read ↗

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cellsSemantic proximity Read ↗

Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cellsSemantic proximity Read ↗

ERK-Mediated Phosphorylation of EZH2 Regulates HER2 Expression on Long-term Genistein-induced Acquired Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.