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Article

Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice.

Molecular imaging - 1 Jan 2000

Choi Clara Y H, Chan Denise A, Paulmurugan Ramasamy, Sutphin Patrick D, Le Quynh-Thu, Koong Albert C, Zundel Wayne, Gambhir Sanjiv S, Giaccia Amato J

Abstract excerpt

Tumor hypoxia plays a crucial role in tumorigenesis. Under hypoxia, hypoxia-inducible factor 1 alpha (HIF-1 alpha) regulates activation of genes promoting malignant progression. Under normoxia, HIF-1 alpha is hydroxylated on prolines 402 and 564 and is targeted for ubiquitin-mediated degradation by interacting with the von Hippel-Lindau protein complex (pVHL). We have developed a novel method of studying the...

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PMID: 19123984
PMCID: PMC4157628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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