Acquired pMHC I complexes greatly enhance CD4(+) Th cell's stimulatory effect on CD8(+) T cell-mediated diabetes in transgenic RIP-mOVA mice.

Abstract excerpt

CD4(+) helper T (Th) cells play pivotal roles in induction of CD8(+) CTL immunity. However, the mechanism of CD4(+) T cell help delivery to CD8(+) T cells in vivo is still elusive. In this study, we used ovalbumin (OVA)-pulsed dendritic cells (DC(OVA)) to activate OT-II mouse CD4(+) T cells, and then studied the help effect of these CD4(+) T cells on CD8(+) cytotoxic T lymphocyte (CTL) responses. We also examined...

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