Article
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.
International journal of cancer - 15 Apr 2009
Kubo Takafumi, Yamamoto Hiromasa, Lockwood William W, Valencia Ilse, Soh Junichi, Peyton Michael, Jida Masaru, Otani Hiroki, Fujii Tetsuya, Ouchida Mamoru, Takigawa Nagio, Kiura Katsuyuki, Shimizu Kenji, Date Hiroshi, Minna John D, Varella-Garcia Marileila, Lam Wan L, Gazdar Adi F, Toyooka Shinichi
Abstract excerpt
We analyzed MET protein and copy number in NSCLC with or without EGFR mutations untreated with EGFR tyrosine kinase inhibitors (TKIs). MET copy number was examined in 28 NSCLC and 4 human bronchial epithelial cell lines (HBEC) and 100 primary tumors using quantitative real-time PCR. Positive results were confirmed by array comparative genomic hybridization and fluorescence in-situ hybridization. Total and...
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