Monitoring "De Novo"APP synthesis by taking advantage of the reversible effect of cycloheximide.

Abstract excerpt

By blocking "de novo" protein synthesis using cycloheximide, we previously described a dynamic model system to monitor turnover of a specific population of the Alzheimer's amyloid precursor protein. Here we show that cycloheximide is nontoxic and its effect is reversible, allowing protein synthesis to reinitiate. Upon cycloheximide removal protein synthesis restarted and by 1 hour the amyloid precursor protein-...

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