Article
INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men.
BMC medical genetics - 23 Dec 2008
Orkunoglu-Suer Funda E, Gordish-Dressman Heather, Clarkson Priscilla M, Thompson Paul D, Angelopoulos Theodore J, Gordon Paul M, Moyna Niall M, Pescatello Linda S, Visich Paul S, Zoeller Robert F, Harmon Brennan, Seip Richard L, Hoffman Eric P, Devaney Joseph M
Abstract excerpt
BACKGROUND: A common SNP upstream of the INSIG2 gene, rs7566605 (g.-10,1025G>C, Chr2:118,552,255, NT_022135.15), was reported to be associated with obesity (Body Mass Index, [BMI]) in a genome-wide association scan using the Framingham Heart Study but has not been reproduced in other cohorts. As BMI is a relatively insensitive measure of adiposity that is subject to many confounding variables, we sought to...
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