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Article

Beyond clinical phenotype: the biologic integratome.

Critical care medicine - 1 Jan 2009

Grimaldi David, Claessens Yann-Erick, Mira Jean-Paul, Chiche Jean-Daniel

Abstract excerpt

Current classification of medical diagnosis derives from observational correlation between clinical syndromes and pathologic analysis. Limited understanding of the molecular determinants of diseases encountered in the critically ill remains a major obstacle to the rationale selection of therapeutic targets. Indeed, many human diseases reflect a disorder in physiologic processes that are known to involve the...

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PMID: 19104224
DOI: 10.1097/CCM.0b013e3181920cca

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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