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PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA

22 Dec 2008

Abstract excerpt

Poly-ADP ribose polymerase 1 (PARP-1) is activated by DNA damage and has been implicated in the repair of single-strand breaks (SSBs). Involvement of PARP-1 in other DNA damage responses remains controversial. In this study, we show that PARP-1 is required for replication fork slowing on damaged DNA. Fork progression in PARP-1(-/-) DT40 cells is not slowed down even in the presence of DNA damage induced by the...

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PMID: 19103807
DOI: 10.1083/jcb.200806068

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